Five hundred people took on the TEWV 10k, which was started by Coronation Street actor Richard Hawley, who played Johnny Connor in the soap.
YO1 Radio were at the start and finish lines, providing the entertainment with music and commentary, and Pure Gym warmed up participants before they took on the 10k.
The first male over the finish line was Dave Parkin, who finished in 37 minutes and seven seconds. Charlotte Bush was first female in 38 minutes and 44 seconds, closely followed by sister Erin in 39 minutes and 19 seconds.
The day then saw hundreds of people cross the finish line, each with their own reason to run.
York FC provided a kick-about for spectators and North Yorkshire Police and North Yorkshire Fire and Rescue Service brought vehicles for the public to explore.
Patrick Scott, deputy chief executive for the Trust, said: “The TEWV 10k was born out of a love of running and yesterday we got to witness the result of that – with hundreds of people crossing the finish line, some raising much needed funds for their chosen charity.
“We believe we are the first NHS Trust to organise a running event in the region and we have been overwhelmed by the response from our participants and their supporters.
“Exercise, and particularly running, is known to have a positive effect on our mental health and we are proud that we were able to stage this run for the local community in York.”